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Why is nefazodone being discontinued?

Why is nefazodone being discontinued?

It’s important to note that the sale of Serzone, the brand medication of Nefazodone, was discontinued in 2003 in the United States due to the rare occurrence of severe liver damage.

What are the ingredients in nefazodone?

Nefazodone hydrochloride tablets, USP is supplied as uncoated round tablets containing either 50 mg, 100 mg, 150 mg, 200 mg, or 250 mg of nefazodone hydrochloride, USP and the following inactive ingredients: colloidal silicon dioxide, ferric oxide (red and/or yellow) as colorants for (50 mg, 150 mg, and 200 mg …

Is nefazodone an SSRI or SNRI?

Nefazodone is chemically unrelated to the serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs), or the monoamine oxidase (MAO) inhibitors. It is chemically related to another antidepressant, trazodone (Desyrel) and shares its actions.

Is trazodone the same as Serzone?

Trazodone is chemically unrelated to the selective serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors). It is chemically related to nefazodone (Serzone) and shares its actions.

What medication is closest to nefazodone?


  • nefazodone (nefazodone) Prescription only. 1 dosage forms. $61.02 is the lowest price near you.
  • 2 alternatives.
  • Viibryd (vilazodone) Prescription only. 67% of people say it’s worth it. 1 dosage forms.
  • Oleptro (trazodone) Prescription only. 73% of people say it’s worth it. 2 dosage forms.

What are the side effects of Serzone?

Dizziness, drowsiness, lightheadedness, nausea, dry mouth, or constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. To reduce dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Is serzone an SSRI or an SNRI?

SERZONE® (nefazodone hydrochloride) is an antidepressant for oral administration with a chemical structure unrelated to selective serotonin reuptake inhibitors, tricyclics, tetracyclics, or monoamine oxidase inhibitors (MAOI)….HOW SUPPLIED.

NDC 0087-0041-31 250 mg white tablet, bottle of 60

What is the closest drug to Serzone?

Is serzone being discontinued?

Reason for posting: Because of concerns of hepatotoxicity, the sale of the antidepressant nefazodone hydrochloride (Serzone) will be discontinued by the manufacturer effective Nov.

What medicine is similar to Serzone?

What drug is similar to Serzone?


  • Bupropion (Wellbutrin SR, Wellbutrin XL, others)
  • Mirtazapine (Remeron)
  • Nefazodone.
  • Trazodone.
  • Vilazodone (Viibryd)
  • Vortioxetine (Trintellix)

Is Serzone being discontinued?

What kind of drugs can you not take with Serzone?

Do not take Serzone if you are taking any of the following drugs: a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate); pimozide (Orap).

When to discontinue MAOI therapy with Serzone?

The safety of SERZONE in long-term use is supported by data from both double-blind and open-label trials involving more than 250 patients treated for at least one year. At least 14 days should elapse between discontinuation of an MAOI and initiation of therapy with SERZONE.

What are monoamine oxidase inhibitors ( MAOIs ) used for?

Monoamine oxidase inhibitors (MAOIs) were the first type of antidepressant developed. They’re effective, but they’ve generally been replaced by antidepressants that are safer and cause fewer side effects. Antidepressants such as MAOIs ease depression by affecting chemical messengers (neurotransmitters) used to communicate between brain cells.

How are monoamine oxidase inhibitors used in Parkinsons Disease?

Certain MAOIs may also be used in conjunction with other medications to help treat Parkinson’s disease (PD) as well as depression associated with PD. What Are MAOIs? Monoamine oxidase inhibitors are a class of drugs primarily used as antidepressants.